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Allopregnanolone

  • CAS:516-55-2
  • Appearance:White to off-white powder
  • Synonym:3β-hydroxy-5α-pregnan-20-one; Brexanolone; Zulresso
  • Molecular Formula:C21H34O2
  • Molecular Weight:318.49
  • Not for private person sale.

    Feature

    Brexanolone is a synthetic form of allopregnanolone. It is an FDA-approved injectable medication specifically for the treatment of postpartum depression. Clinical studies have shown that after injection, it can take effect quickly within a few hours, and 75% of patients reported improvement in their symptoms.
    Its main ingredient is Allopregnanolone, which is a pharmaceutical raw material used for postpartum depression.
    Allopregnanolone is a hormone that helps relieve depression and anxiety by inhibiting neural activity.

    Specification-COA

    ItemResult
    NameAllopregnanolone powder
    AppearanceWhite to off-white powder
    IdentificationInhouse
    Assay≥98%(HPLC)
    Purity(HPLC)≥98%
    Specific RatationD27 +91.2° (c=0.4 in ethanol)
    Related SubstanceTotal≤2% Individual≤0.5%
    Loss on drying≤0.5%
    Melting Point200°C 
    Boiling Point431.2ºC at 760mmHg
    PKa15.12±0.70(Predicted)
    Density1.1 g/cm3
    StorageCool and Dry
    Product CategoriesSteroids and steroid derivatives; Pharmaceuticals
    Synonym3β-hydroxy-5α-pregnan-20-one;Brexanolone; Allopregnanolone;Zulresso

    Function and Application

    1. Antidepressant and antianxiety. From a pharmacological point of view, Allopregnanolone acts as a neurosteroid, a modulator of GABAA receptors, which can activate GABAA receptors inside and outside the synapse and produce antidepressant and antianxiety effects.
      It can relieve the symptoms of postpartum depression in a shorter period of time and has a fast onset of action.
    2. Antiviral effect on influenza virus. Studies have found that allopregnanolone has biological activity that inhibits the replication of influenza A virus.
      It exerts antiviral effects by interfering with the transport of viral nucleoprotein (NP).
      In short, allopregnanolone, as a new type of influenza virus NP inhibitor, has potential development and application value.

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