Features

L Ergothioneine (EGT) is a natural sulfur-containing amino acid small molecule substance that exists in microbial cells and animals and plants. As one of the few long-acting natural antioxidants that can enter mitochondria and cell nuclei. It shows potential for application in supplements, skin care products, and biomedicine.

EGT can be synthesized by microorganisms such as fungi, cyanobacteria, and actinomycetes.

The products supplied by our company are characterized by high purity and high stability, with a content of more than 99%. And each batch is tested to ensure the stability of the raw materials. The pure product is white, odorless crystals, easily soluble in water, and has good pH stability and thermal stability.

Specification-COA

Items	Specifications	Test Results	Methods
Purity	≥99.9%	99.92%	HPLC(Internal Standard Method)
Physical & Chemical Control
Appearance	White  crystal	Conform	Visual observation
Smell	Characteristic odor	Conform	Nose  smells
pH(50mg/mL,20℃)	6.0-7.5	6.38	pH meter
Melting  Point   (Decompose)	270-271℃	270.4℃	Melting point detector
Optical Rotation	[a]D≥(+)122°(c= 1,H₂O)	+124.9°	Polarimeter (c= 1,H₂O)
Crystallite  size	100% pass rate for 50 mesh	Conform	Sieve
Density	0.55-0.75g/mL	0.66	Bulk density meter
Loss on Drying	<0.5%	0.07%	TGA
Total Residual  Solvents	≤200 ppm	50.06 ppm	GC
Heavy Metals Control:
Arsenic	≤1 ppm	Conform	ICP
Lead	≤1 ppm	Conform	ICP
Mercury	≤0.2 ppm	Conform	ICP
Cadmium	≤0.3 ppm	Conform	ICP
Total Heavy Metals	≤10 ppm	Conform	ICP
Microbiological Control:
E.coli	Negative/25g	Conform	USP<62>
Staphylococcus aureus Rosenbach	Negative/25ç	Conform	USP<62>
Salmonella	Negative/25g	Conform	USP<62>
P, aeruginosa	Negative/25g	Conform	USP<62>
Total Coliform	<100 CFU/g	Conform	USP<62>
Total Yeast and Mold  Count	≤100 CFU/s	Conform
Total Viable Aerobic  Count	≤1000 CFU/ç	Conform
Storage: Sealed and stored in a cool and dry place, protected from sunlight and moisture

Functions

1. Ergothioneine EGT is a natural and highly effective antioxidant. In vitro experiments show that it has a strong scavenging ability for hydroxyl free radicals. Compared with other thiol compounds such as glutathione, EGT has higher antioxidant activity.
   The mechanism is to carry the transporter OCTN-1 in fibroblasts into cells and mitochondria to remove reactive oxygen free radicals, thereby protecting mitochondrial DNA.
2. Tests show that it can protect mitochondria, promote the production of type III collagen in the skin, and improve skin texture, thereby achieving the effect of anti-photoaging and delaying skin aging.
3. Immunomodulatory effect. EGT can regulate the microenvironment and enhance immune function.
4. EGT can also inhibit the inflammatory response of adipocytes. By activating the silent information regulator 6 and SIRT6 pathway in osteoarthritis chondrocytes, it inhibits NF-κB activity. Thereby significantly weakening the inflammatory response and inhibiting the progression of osteoarthritis.

Versatile Applications of L-Ergothioneine

L-Ergothioneine is a versatile antioxidant with a wide range of applications, particularly in skincare, nutritional supplements, and functional foods. Its powerful antioxidant and anti-inflammatory properties make it an ideal ingredient for promoting health and wellness.

1. Skincare Products

• Anti-Aging Products: Helps reduce free radical damage, slows down the aging process, and improves skin elasticity and firmness.
• Repair Serums and Creams: Enhances the skin barrier, repairs damaged skin, and reduces inflammation, promoting skin health.
• Sensitive Skin Care: Its anti-inflammatory effects make it effective for soothing irritation and redness, making it ideal for sensitive skin.
• Brightening and Whitening Products: Reduces skin discoloration caused by oxidative stress, evens out skin tone, and enhances radiance.

2. Nutritional Supplements

• Anti-Aging Supplements: Helps slow down cellular aging, supports cell vitality, and boosts immune function.
• Energy Boosting Supplements: Improves cellular energy production, helping to increase vitality and reduce fatigue.
• Immune System Support: Enhances immune function, protecting the body against external pathogens and stressors.
• Anti-Inflammatory Supplements: Reduces systemic inflammation, particularly beneficial for joint and chronic inflammatory conditions.

3. Functional Foods

• Functional Beverages: Such as anti-aging drinks, energy drinks, and immunity-boosting beverages, providing cellular protection and delaying aging.
• Health Snacks: Like nuts, energy bars, and dried fruits enriched with L-Ergothioneine for additional antioxidant support.
• Fortified Foods: Added to breakfast cereals, health drinks, yogurt, and other fortified foods, making it easy for consumers to incorporate into their daily diet.

4. Hair Care Products

• Conditioners and Hair Masks: Protects hair from oxidative damage, keeping it shiny, healthy, and preventing premature aging of the hair.
• Hair Growth Solutions: Helps repair damaged hair, stimulate circulation in the scalp, and promote healthy hair growth.

5. Eye Care Products

• Eye Supplements: Helps protect the eyes from oxidative damage and supports long-term eye health, potentially slowing age-related eye conditions.
• Eye Creams: Reduces fine lines and puffiness around the eyes, enhancing the youthful appearance of the delicate skin around the eyes.

6. Oral Care Products

• Toothpastes and Mouthwashes: Helps reduce oxidative damage to teeth and gums, minimizes inflammation, and promotes overall oral health.

7. Pet Care Products

• Pet Supplements: Supports immune function, promotes skin and coat health, and reduces signs of aging in pets.
• Pet Skincare Products: Helps alleviate skin irritation and inflammation, improving the overall health and appearance of pets’ skin and fur.

Antioxidant Benefits of L-Ergothioneine

Why L-ergothioneine is a Must-Have Ingredient in Skincare?

L-Ergothioneine is a powerful natural antioxidant widely used in skincare products. It works by neutralizing free radicals and reducing oxidative damage to the skin, helping to slow down the aging process and enhance skin health. L-Ergothioneine strengthens the skin's barrier, protecting it from environmental stressors like UV rays and pollution, and minimizes cellular damage. Long-term use of skincare products containing L-Ergothioneine can improve skin tone, boost radiance, and increase elasticity, leaving the skin looking younger and healthier. As a result, it has become a key ingredient in many anti-aging and reparative skincare formulations.

L-Ergothioneine vs. Other Antioxidants

L-Ergothioneine is rapidly gaining recognition as a powerful antioxidant in the skincare industry. While other well-known antioxidants like Vitamin C and Vitamin E have long been celebrated for their benefits, L-Ergothioneine offers several distinct advantages that make it stand out in protecting and rejuvenating the skin.

1. Stronger Cellular Protection

L-Ergothioneine is often referred to as a "master antioxidant" because of its ability to selectively target and protect mitochondria, the powerhouse of cells. Unlike Vitamin C and E, which primarily neutralize free radicals in the skin’s outer layers, L-Ergothioneine works at a deeper cellular level, offering long-lasting protection and repair. This unique ability to protect mitochondria makes it an essential component in preventing cellular damage and slowing down the aging process.

2. Superior Antioxidant Power

While Vitamin C and E are excellent at fighting oxidative stress, L-Ergothioneine has been found to be more stable and potent in neutralizing free radicals. It can protect the skin against a wider range of harmful environmental stressors, including UV rays, pollution, and toxins, providing superior overall protection against skin aging.

3. Enhanced Skin Barrier Function

L-Ergothioneine not only neutralizes free radicals but also helps to strengthen the skin's natural barrier. This makes it particularly beneficial for sensitive and compromised skin, providing long-term protection from environmental damage. In contrast, while Vitamin C and E are great for brightening and repairing, they may not offer the same level of barrier protection, especially in sensitive or damaged skin.

4. Anti-Inflammatory and Healing Properties

L-Ergothioneine is also known for its anti-inflammatory effects, helping to calm and repair the skin. It works synergistically with other antioxidants to reduce redness, irritation, and inflammation, making it ideal for sensitive or acne-prone skin. While Vitamin C is known for its brightening and collagen-boosting effects, and Vitamin E for its moisturizing properties, L-Ergothioneine's ability to soothe inflammation and heal the skin is what sets it apart.

5. Long-Term Skin Health

Unlike other antioxidants that may lose their efficacy over time due to environmental exposure, L-Ergothioneine is remarkably stable and can remain effective in your skincare routine for longer periods. This makes it an ideal choice for anti-aging treatments and long-term skin health maintenance.

6. Works in Conjunction with Other Antioxidants

L-Ergothioneine pairs exceptionally well with other antioxidants like Vitamin C and E. When combined, these antioxidants work synergistically to enhance the overall effectiveness of your skincare products. For instance, Vitamin C brightens the skin and promotes collagen production, while Vitamin E nourishes and hydrates, and L-Ergothioneine provides deep cellular protection and longevity.