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Urolithin A

  • CAS No.:1143-70-0
  • Molecular formula: C13H8O4
  • Molecular weight: 228.20000
  • Purity:98%
  • Both powder and capsules are available
  • OEM ODM Available

    Features

    Urolithin  A is a natural metabolite of ellagitannins found in pomegranates and nuts. In the human body, it is a special substance metabolized from intestinal microorganisms.

    The production process of urolithin A includes fermentation process and chemical synthesis process. Currently, large-scale production of urolithin A raw materials is mainly based on chemical synthesis processes.

    In terms of structure, it is the same as the compound formed endogenously after ellagitannins and ellagic acid.

    The color of urolithin A powder varies from light yellow, yellow to white and grayish white.

    Application

    Used in medicine and healthcare products

    1. Application in dietary supplements:
      Urolithin A has been certified GRAS by the U.S. Food and Drug Administration. It is suitable for adults aged 40 and above. Or as an ingredient in certain foods or used in dietary products to enhance muscle strength, increase endurance and anti-aging.
    2. Application in skin care:
      Aiming to reduce wrinkles and improve skin texture, the main use of urolithin A is as a skin protectant and anti-aging and anti-wrinkle agent.
    3. Lactobacillus plantarum can metabolize ellagitannins in the diet to produce urolithin A. Therefore, it can be applied to products that delay aging, extend lifespan, and promote exercise.

    Flow Chart for Urolithin A

    Functions

    • Positive effects on mitochondria:
      It can induce mitophagy, a selective form of autophagy that helps to remove damaged mitochondria. Thereby maintaining mitochondrial health and cellular homeostasis to support mitochondrial health.
    • Anti-aging function
      It has anti-aging effects on skin tissue, organs, immune system, and individual lifespan.
    • In addition,it has potential effects in the prevention of many metabolic diseases.
    • Anti-inflammatory effect
      UA plays a role in the treatment of various inflammatory conditions including brain, fat, heart, intestines, and liver tissues.
    • Neuroprotective effect
      UA can increase the survival rate of neurons stimulated by oxidative stress and has good neuroprotective function. Therefore, it has a positive role in the treatment of neurodegenerative diseases including Alzheimer's disease and Parkinson's disease.

    Specification-COA

    Testing ItemsSpecificationsResults
    AppearanceOff-white to light yellow powderConforms
    Identification1 HNMR confirms to structureConforms
    LCMSLCMS Conforms to MWConforms
    Water≤0.5%0.08%
    Residue on ignition≤0.2%0.11%
    Purity (HPLC)≥98.0%99.91%
    Heavy metals
    Pb≤0.5ppm0.0576ppm
    As≤ 1.5ppm0.022ppm
    Cd≤0.5ppm<0.005ppm
    Hg≤0. 1ppm0.0122ppm
    Residual solvents
    Methanol≤3000ppmNot detected
    TBME≤ 1000ppmNot detected
    Toluene≤890ppmNot detected
    DMSO≤5000ppm460ppm
    Acetic Acid≤5000ppm1050ppm
    ConclusionThis product conforms to the specifications.

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